From what I understand, the Matrix edition does not require CDs. In fact, if you do the digital download, you don't even have CDs to insert if you wanted to.
If you plan to stay with the "classic" Talonsoft editions, you can try getting a virtual CD program. You basically make a virtual copy of the CD and the software mimics a CD-Rom drive. You still have to "insert" the virtual CDs between games, but it is lot easier than inserting a real CD. There is commercial virtual CD software out there (e.g. Gamedrive by Farstone), and shareware VCD programs. I use GameDrive.
Changing to the virtual CD arrangement also can require reinstalling the games from the virtual CDs because the Talonsoft versions don't just look for the CDs, they look for the CD in the drive it was installed from. So if your real CD-drive is D:, and the virtual is E:, the original install won't work. There are some workarounds with reassigning drive letters if you are comfortable with that, and there are probably some other workarounds as well.